α-conotoxin GI has been isolated from the venom of the cone snail Conus geographus. This conotoxin acts on postsynaptic membranes, which bind to the nicotinic acetylcholine receptor (nAChR). It Inhibits nAChR currents. The highest affinity site for Cis the α/δ site on mouse muscle-derived BC3H-1 receptor, and the other site (α/γ site) on nicotinic receptors from Torpedo californica electric organ.
Peptides & proteins
alpha conotoxin GI
Groebe, D. R., et al. (1997). Biochemistry; Pardi, A., et al. (1989) Biochemistry; Nishiuchi, Y and Sakakibara, S. (1982). FEBS Lett