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Hainantoxin IV

Hainantoxin IV
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Size: 1.0 mg
$1385.00
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Catalogue number:
12HTX001-01000
Name:
Hainantoxin IV
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Hainantoxin-IV (HNTX-IV) is a peptide that was originally isolated from the venom of the Chinese bird spider Ornithoctonus hainana Liang (Selenocosmia hainana Liang). It has been reported that this peptide is a potent antagonist of tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels (VGSCs). It binds to TTX-S with an IC50value of 34 nM in adult rat dorsal root ganglion (DRG) neurons. Tetrodotoxin-resistant (TTX-R) voltage-gated sodium channels are not affected by hainantoxin IV. It probably interacts with the site 1 through a mechanism quite similar to that of TTX without affecting the activation and inactivation kinetics.

Product Type:
Peptides & proteins
Storage Temp:
RT
Molecular Weight:
3987.6 Da
Reference:
Dongling Li, et al. Structure-Activity Relationships of Hainantoxin-IV and Structure Determination of Active and Inactive Sodium Channel Blockers. JBC Papers in Press; Wang W., et al. (2003) Determination of disulfide bridges of two spider toxins: Hainantoxin-III and Hainantoxin-IV. J Venom Anim Toxins incl Trop