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Phlotoxin-1

Catalogue number:
PHX001-00500
Size:
500 µg
Product is available in:
  • USA
  • Canada
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Phlotoxin-1 is a potent blocker of Nav1.7 channel. Phlotoxin-1 is a new member of the NaSpTx-1 family. Phlotoxin-1 has been purified originally from the venom of Phlogiellus sp., Theraphosidae Selenocosmiinae (endemic to Papua New Guinea). Phlotoxin-1 inhibits Nav1.7 with an IC50 value of 39 ± 2 nM. Photoxin-1 inhibition of Nav1.7 channels expressed in a mammalian cell line. Average dose-response curve of hNav1.7 current block by Photoxin-1. A sigmoid Hill fit provides an IC50 value of 39 ± 2 nM and a Hill value of 1.53. Numbers of cells per concentration: 4 to 8

Product Type:

Peptides & proteins