www.mayflowerbio.com
Sales & Support: 314-485-5210

*

MG-132

Supplier:
Catalogue number:
10-1309-02
Size:
25 mg
Product is available in:
  • USA
  • Canada
$200.00 Shipping is calculated in checkout

Proteasome inhibitor

Product Type:

Biochemicals & reagents

CAS Number:

133407-82-6

Alternative Names:

Z-Leu-Leu-Leu-CHO

Range:

1) Tsubuki et al. (1996), Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-leucine and tri-leucine ; J. Biochem., 119 572 2) Wu et al. (2010), Macroautophagy and ERK phosphorylation counteract the antiproliferative effect of proteasome inhibitor in gastric cancer cells; Autophagy, 6 228 3) Meriin et al. (1998), Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis; J. Biol. Chem., 273 6373 4) Fiedler et al. (1998), Inhibition of TNF-alpha-induced NF-kappaB activation and IL-8 release in A549 cells with the proteasome inhibitor MG-132; Am. J. Respir. Cell Mol. Biol., 19 259

Limit of Detection:

475.63

Storage Temperature:

-20°C (des.)

Additional Information:

MG-132 (133407-82-6) is a specific inhibitor of the chymotrypsin-like activity of the 20S proteasome (IC50=100 nM with Z-LLL-AMC as substrate).1 Also inhibits calpain (IC50=1.25 μM)1 Suppresses gastric cancer cell proliferation and induces macro-autophagy2. Activates stress kinases and induces Hsp72.3 Induces neurite outgrowth.1 MG-132 blocks NFκB activation by blocking IκB proteolysis (IC50=3 μM).4 Cell permeable.

Related Content: