Biochemicals & reagents
1) Hande (1998) Etoposide: four decades of development of a topoisomerase II inhibitor:; Eur. J. Cancer 34, 1514 / 2) Smith et.al. (1994) Etoposide-induced cell cycle delay and arrest-dependent modulation of DNA topoisomerase II in small-cell lung cancer cells. Br J Cancer. 70 914
Etoposide (33419-42-0) is a chemotherapeutic agent that forms a ternary complex with DNA and topoisomerase II, preventing re-ligation of DNA strands causing DNA cleavage. Etoposide blocks the cell cycle in S-phase and G2-phase.