NVP-BEZ235 is a PI 3-kinase (PI3K) tyrosine kinase inhibitor and shows dual PI3K/mTOR inhibition. NVP-BEZ235 also inhibits ATR. However, NVP-BEZ235 has been shown to be poor inhibitory to Akt and PDK1. NVP-BEZ235 shows high target specificity and demonstrates antiproliferative activity against tumor cell lines in animal models of cancer.
Peptides & proteins
BEZ235, Dactolisib, 2-methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile
1) Goto, S., et al. 1996. Anticancer Res. 16(5A): 2507-2511. PMID: 8917343; 2) Metz, MZ., et al. 2013. Stem Cells Transl Med. 2(12): 983-992. PMID: 24167321; 3) Hong, SH., et al. 2013. Cancer Gene Ther. 20(12): 678-682. PMID: 24310061
-20°C. Keep away from direct sunlight.
12 months from receipt