LY411575
LY411575 is a potent gamma secretase inhibitor. It is able to block Notch activation and reduces A beta/42 post treatment (acute or chronic). Notch signaling is a pathway known to regulate both differentiation and proliferation of cells in diverse adult tissues. LY411575 has been shown to promote goblet cell differentiation in mice intestine. It has also been observed to promote neural differentiation of mouse embryonic stem cells (ESC).
- Datasheet: view or download
Peptides & proteins
209984-57-6
LY-411575, LY 411575, LSN-411575, N-2((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-l-alaninamide
1) Curry, CL., et al. 2005. Oncogene. 24(42): 6333-6344. PMID: 15940249; 2) Abranches, E., et al. 2009. PLoS One. 4(7): e6286. PMID: 19621087
479.48
-20°C. Keep away from direct sunlight.
12 months from receipt