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A769662

Catalogue number:
SM08-200
Size:
200 mg
Product is available in:
  • USA
  • Canada
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A769662 is a potent, reversible activator of AMP-activated protein kinase (AMPK). It activates beta1-containing AMPK complexes, but induces glucose uptake via a PI3 kinase-dependent pathway. A769662 inhibits 3T3-L1 adipocyte differentiation and may be used to treat obesity. It also inhibited the function of the 26S proteasome via an AMPK-independent mechanism.

Product Type:

Peptides & proteins

CAS Number:

844499-71-4

Alternative Names:

A-769662, 6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile

Range:

1) Göransson, O., et al. 2007. J. Biol. Chem. 282: 32549-32560. PMID: 17855357; 2) Treebak, J.T., et al. 2009. Am. J. Physiol. Cell Physiol. 297: 1041-1052. PMID: 19657063; 3) Benziane, B., et al. 2009. Am. J. Physiol. Cell Physiol. 297: 1554-1566. PMID: 19828836; 4) Rajamohan, F., et al. 2010. Protein Expr. Purif. 73: 189-197. PMID: 20451617

Limit of Detection:

360.39

Storage Temperature:

-20°C. Keep away from direct sunlight.

Shelf Life:

12 months from receipt