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Catalogue number:
2 mg
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CYT387 is an ATP competitive inhibitor of JAK1 and JAK2 (Janus kinases). CYT387 inhibits the proliferation of parental Ba/F3 cells (Ba/F3-wt) stimulated by IL-3. Furthermore, CYT387 also causes the inhibition of cell proliferation in cell lines constitutively activated by JAK2 or MPL signaling. CYT387 has been shown to inhibit erythroid colony growth in-vitro. CYT387 inhibits erythropoiesis from induced pluripotent stem cells (iPSC), but has less inhibitory effect on the self-renewal of CD34+ hematopoietic progenitors.

Product Type:

Peptides & proteins

CAS Number:


Alternative Names:

CYT 11387, Cyt-387, N-(Cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]benzamide


1) Wang, Y., et al. 2007. Life Sci. 80(22): 2067-2075. PMID: 17459422; 2) Bennett, BL., et al. 2001. Proc Natl Acad Sci U S A. 98(24): 13681-13686. PMID: 11717429

Limit of Detection:


Storage Temperature:

-20°C. Keep away from direct sunlight.

Shelf Life:

12 months from receipt