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CYT387

Catalogue number:
SM44-2
Size:
2 mg
Product is available in:
  • USA
  • Canada
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CYT387 is an ATP competitive inhibitor of JAK1 and JAK2 (Janus kinases). CYT387 inhibits the proliferation of parental Ba/F3 cells (Ba/F3-wt) stimulated by IL-3. Furthermore, CYT387 also causes the inhibition of cell proliferation in cell lines constitutively activated by JAK2 or MPL signaling. CYT387 has been shown to inhibit erythroid colony growth in-vitro. CYT387 inhibits erythropoiesis from induced pluripotent stem cells (iPSC), but has less inhibitory effect on the self-renewal of CD34+ hematopoietic progenitors.

Product Type:

Peptides & proteins

CAS Number:

1056634-68-4

Alternative Names:

CYT 11387, Cyt-387, N-(Cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]benzamide

Range:

1) Ye, Z., et al. 2014. Stem Cells. 32(1): 269-278. PMID: 24105986; 2) Barosi, G. 2012. Expert Rev Hematol. 5(3): 313-324. PMID: 22780211

Limit of Detection:

414.46

Storage Temperature:

-20°C. Keep away from direct sunlight.

Shelf Life:

12 months from receipt