Cyclosporin A is a non-polar cyclic oligopeptide metabolite. It possesses potent immunosuppressive properties, affecting primarly T-lymphocytes. Cyclosporin A is the primary tool used to prevent rejection following solid organ and/or bone marrow transplantation. Cyclosporin A inhibits phosphatase activity of calcineurin. This small molecule also inhibits formation and opening of the mitochondrial permeability transition pore (MPTP).
Peptides & proteins
Cyclosporine, Antibiotic S 7481F1, Ciclosporin A, Ramihyphin A, CsA
1) Anastasia, L., et al. 2010. Cell Death Diff. 17(8): 1230-1237. PMID: 20168332; 2) Woillard, J., et al. 2014. Br J Clin Pharmacol. epub. PMID: 24698009
-20°C. Keep away from direct sunlight.
12 months from receipt