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Cyclosporin A (CsA)

Catalogue number:
SM43-5000
Size:
5 g
Product is available in:
  • USA
  • Canada
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Cyclosporin A is a non-polar cyclic oligopeptide metabolite. It possesses potent immunosuppressive properties, affecting primarly T-lymphocytes. Cyclosporin A is the primary tool used to prevent rejection following solid organ and/or bone marrow transplantation. Cyclosporin A inhibits phosphatase activity of calcineurin. This small molecule also inhibits formation and opening of the mitochondrial permeability transition pore (MPTP).

Product Type:

Peptides & proteins

CAS Number:

59865-13-3

Alternative Names:

Cyclosporine, Antibiotic S 7481F1, Ciclosporin A, Ramihyphin A, CsA

Range:

1) Anastasia, L., et al. 2010. Cell Death Diff. 17(8): 1230-1237. PMID: 20168332; 2) Woillard, J., et al. 2014. Br J Clin Pharmacol. epub. PMID: 24698009

Limit of Detection:

1202.61

Storage Temperature:

-20°C. Keep away from direct sunlight.

Shelf Life:

12 months from receipt