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GSK429286A

Catalogue number:
SM21-2
Size:
2 mg
Product is available in:
  • USA
  • Canada
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GSK429286A is a cell-permeable, selective Rho-associated kinase (ROCK) inhibitor, active for ROCK1 and ROCK2. GSK429286A is a more selective ROCK2 inhibitor than the widely utilized ROCK inhibitor Y-27632 as assessed on kinase-specificity panel, and does not significantly inhibit LRRK2. GSK429286A significantly inhibits rat aortic ring dilation and reduces mean arterial pressure in the spontaneously hypertensive rats (SHRs).

Product Type:

Peptides & proteins

CAS Number:

864082-47-3

Alternative Names:

GSK 429286, GSK-429286, dihydropyridone indazole, N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-(4-(trifluoromethyl)phenyl)-1,4,5,6-tetrahydropyridine-3-carboxamide

Range:

1) Nichols, RJ., et al. 2009. Biochem J. 424(1): 47-60. PMID: 19740074; 2) Sharon-Frilling, R. and Shenk, T. 2014. Proc Natl Acad Sci USA. 111(12): E1140-1148. PMID: 24616524

Limit of Detection:

432.37

Storage Temperature:

-20°C. Keep away from direct sunlight.

Shelf Life:

12 months from receipt