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GSK429286A

Catalogue number:
SM21-10
Size:
10 mg
Product is available in:
  • USA
  • Canada
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GSK429286A is a cell-permeable, selective Rho-associated kinase (ROCK) inhibitor, active for ROCK1 and ROCK2. GSK429286A is a more selective ROCK2 inhibitor than the widely utilized ROCK inhibitor Y-27632 as assessed on kinase-specificity panel, and does not significantly inhibit LRRK2. GSK429286A significantly inhibits rat aortic ring dilation and reduces mean arterial pressure in the spontaneously hypertensive rats (SHRs).

Product Type:

Peptides & proteins

CAS Number:

864082-47-3

Alternative Names:

GSK 429286, GSK-429286, dihydropyridone indazole, N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-(4-(trifluoromethyl)phenyl)-1,4,5,6-tetrahydropyridine-3-carboxamide