www.mayflowerbio.com
Sales & Support: 314-485-5210

*

DAPT

Catalogue number:
SM15-50
Size:
50 mg
Product is available in:
  • USA
  • Canada
$654.00 Shipping is calculated in checkout

DAPT is a potent and specific inhibitor of gamma-secretase. This reduces antibody levels in-vivo in plasma and cerebrospinal fluid. It blocks the proteolytic processing of neurotrophin receptor alike death domain protein (NRADD). DAPT causes neural cells to commit to neuronal differentiation.

Product Type:

Peptides & proteins

CAS Number:

208255-80-5

Alternative Names:

N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester

Range:

1) Dovey, H.F., et al. 2001. J. Neurochem. 76: 173-181. PMID: 11145990; 2) Geling, A., et al. 2002. EMBO Rep. 3: 688-694. PMID: 12101103; 3) Lanz, T.A., et al. 2003. J. Pharmacol. Exp. Ther. 305: 864-871. PMID: 12626636; 4) Gowrishankar, K., et al. 2004. J. Cell. Sci. 117: 4099-4111. PMID: 15280425; 5) De Smedt, M., et al. 2005. Blood. 106: 3498-3506. PMID: 16030192; 6) El Mouedden, M., et al. 2006. Curr. Pharm. Des. 12: 671-676. PMID: 16472156

Limit of Detection:

432.46

Storage Temperature:

-20°C. Keep away from direct sunlight.

Shelf Life:

12 months from receipt