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DAPT

DAPT
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Size: 2 mg
$55.00
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Catalogue number:
SM15-2
Name:
DAPT
Supplier:
Availability:

DAPT is a potent and specific inhibitor of gamma-secretase. This reduces antibody levels in-vivo in plasma and cerebrospinal fluid. It blocks the proteolytic processing of neurotrophin receptor alike death domain protein (NRADD). DAPT causes neural cells to commit to neuronal differentiation.

Data sheet:

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Product Type:
Peptides & proteins
CAS Number:
208255-80-5
Alternative Names:
N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester
Storage Temp:
-20°C. Keep away from direct sunlight.
Molecular Weight:
432.46
Material Safety Data Sheet:
Reference:
1) Dovey, H.F., et al. 2001. J. Neurochem. 76: 173-181. PMID: 11145990; 2) Geling, A., et al. 2002. EMBO Rep. 3: 688-694. PMID: 12101103; 3) Lanz, T.A., et al. 2003. J. Pharmacol. Exp. Ther. 305: 864-871. PMID: 12626636; 4) Gowrishankar, K., et al. 2004. J. Cell. Sci. 117: 4099-4111. PMID: 15280425; 5) De Smedt, M., et al. 2005. Blood. 106: 3498-3506. PMID: 16030192; 6) El Mouedden, M., et al. 2006. Curr. Pharm. Des. 12: 671-676. PMID: 16472156
Shelf Life:
12 months from receipt