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Vandetanib

Catalogue number:
SM107-500
Size:
500 mg
Product is available in:
  • USA
  • Canada
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Vandetanib is an antagonist of VEGFR and EGFR families. Specifically inhibits kinase activity of Flk-1. It is also an inhibitor of Flt-4. Vandetanib is not sensitive to PDGFR beta, Flt1, Tie-2 and FGFR1, while almost has no activity against MEK, CDK2, c-Kit, erbB2, FAK, PDK1, Akt and IGF-1R. Vandetanib has been shown to influence in the osteoblast differentiation process in-vitro.

Product Type:

Peptides & proteins

CAS Number:

443913-73-3

Alternative Names:

Caprelsa, Zactima, ZD6474, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine

Range:

1) Wedge, SR., et al. 2002. Cancer Res. 62(16): 4645-4655. PMID: 12183421; 2) Arbab, AS. 2012. Histol Histopathol. 27(5): 549-557. PMID: 22419019; 3) Alemán, JO. et al. 2014. Endocr Relat Cancer. 21(3): R247-259. PMID: 24478055

Limit of Detection:

475.35

Storage Temperature:

-20°C. Keep away from direct sunlight.

Shelf Life:

12 months from receipt