www.mayflowerbio.com
Sales & Support: 314-485-5210

*

U0126

Catalogue number:
SM106-5
Size:
5 mg
Product is available in:
  • USA
  • Canada
$57.00 Shipping is calculated in checkout

U0126 is a selective MAP Kinase inhibitor, displaying a preference for MEK-1 and MEK-2. It is known that U0126 binds to MEK in a noncompetitive manner compared to ATP. Studies suggest that U0126 antagonizes the transcription of AP-1, via the inhibition of MEK. In addition, U0126 has been observed to inhibit promoters containing an AP-1 response element, while in contrast having no effect on promoters that lack an AP-1 response group. U0126 is an activator of PGC-1, mtTFA and Nuclear Respiratory Factor. Inhibition of MEK/ERK activity by specific MEK inhibitors PD98059 and U0126 rapidly causes the loss of human embryonic stem cells (hESC) pluripotency, acting as a promoter of hESC differentiation. U0126 is also useful in neuronal studies in mice since it displays inhibitory effects against oxidative stress.

Product Type:

Peptides & proteins

CAS Number:

109511-58-2

Alternative Names:

U-0126, Succinonitrile, 1,4-Diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)-butadiene

Range:

1) Duncia, JV., et al. 1998. Bioorg Med Chem Lett. 8(20): 2839-2844. PMID: 9873633; 2) Satoh, T., et al. 2000. Neurosci Lett. 288(2): 163-166. PMID: 10876086; 3) Zhang, XZ. 2010. Reprod Biomed Online. 21(1): 26-36. PMID: 20462797; 4) Wu, HM., et al. 2014. J Cell Mol Med. PMID: 24725889

Limit of Detection:

380.49

Storage Temperature:

-20°C. Keep away from direct sunlight.

Shelf Life:

12 months from receipt