Fibroblast Growth Factor 8 (FGF-8) is a critical factor in embryonic development of the brain structure and also required for normal development of the eye, ear and limbs. FGF-8 has broad functions that involve proliferation, differentiation and cell migration. Inappropriate expression of FGF-8 is linked to increased tumor growth and angiogenesis. There is 100% homology between human and mouse FGF-8. FGF-8 is a non-glycosylated protein containing 194 amino acids, with a total molecular weight of 22.5 kDa.
Peptides & proteins
Androgen-induced growth factor, AIGF, Heparin-binding growth factor 8, HBGF-8
NAME: Fibroblast Growth Factor-8; ACCESSION/UNIPROT#: P55075; EXPRESSION SYSTEM: E.coli; FORMAT: Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 5 mM sodium phosphate, 50mM soldium chloride, pH 7.5. Reconstitute in sterile water at 0.1 mg/mL.; TESTING: BALB/c 3T3 cell proliferation with an acceptance criteria of 150 ng/mL (ED50), 6.7 x 10^5 units/mg.; #AA: 194; SEQUENCE: MQVTVQSSPN FTQHVREQSL VTDQLSRRLI RTYQLYSRTS GKHVQVLANK RINAMAEDGD PFAKLIVETD TFGSRVRVRGAETGLYICMN KKGKLIAKSN GKGKDCVFTE IVLENNYTAL QNAKYEGWYM AFTRKGRPRK GSKTRQHQRE VHFMKRLPRG HHTTEQSLRFEFLNYPPFTR SLRGSQRTWA PEPR