Interleukin-1 alpha (IL-1 alpha) is constitutively expressed by epithelial cells, but can also be produced by most other cells upon stimulation. IL-1 alpha and IL-1 beta are two distinct and independently regulated gene products that comprise IL-1 and signal through the Type 1 IL-1 receptor (IL-1R1). Although IL-1 alpha is cell associated and IL-1 beta is secreted, they have nearly identical biological activity in that they induce adhesion molecule expression on epithelial cells, control fever induction, and play a role in arthritis and septic shock. Signaling activated by the IL-1R1 promotes these activities through a MYD88 signaling pathway similar to those associated with Toll receptors. Recombinant human IL-1 alpha is a non-glycosylated single chain protein.
Peptides & proteins
IL-1F1, FAF, BAF, LEM, LAF
NAME: Interleukin-1 alpha; ACCESSION/UNIPROT#: P01583; EXPRESSION SYSTEM: E.coli; FORMAT: Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, pH 7.5. Reconstitute in sterile water at 0.1 mg/mL.; TESTING: D10S cell proliferation with an acceptance criteria of 50 pg/mL (ED50), 2.0 x 10^7 units/mg.; #AA: 159; SEQUENCE: SAPFSFLSNV KYNFMRIIKY EFILNDALNQ SIIRANDQYL TAAALHNLDE AVKFDMGAYK SSKDDAKITV ILRISKTQLY VTAQDEDQPV LLKEMPEIPK TITGSETNLL FFWETHGTKN YFTSVAHPNL FIATKQDYWV CLAGGPPSIT DFQILENQA