GDF-15

Growth and Differentiation Factor 15 (GDF-15) is a TGF beta family member, made by the placenta and heart tissues, that has a role in regulating inflammatory and apoptotic pathways. GDF-15 has become an emerging marker of early heart disease and has the potential of being used as a molecule for screening patients for early heart failure. Recombinant human GDF-15 D is a non-glycosylated, disulfide linked homodimer. There is a His to an Asp substitution at position 7.