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IL-1 β (AF)

IL-1 β (AF)
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Size: 1 mg
$4325.00
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Catalogue number:
GFH167AF-1000
Name:
IL-1 β (AF)
Supplier:
Availability:

Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine produced in response to inflammatory agents by a variety of cells, including monocytes, macrophages, and dendric cells (DCs). IL-1 beta and IL-1 alpha are two distinct and independently regulated gene products that comprise IL-1 and signal through the Type 1 IL-1 receptor (IL-1R1). Although IL-1 alpha is cell associated and IL-1 beta is secreted, they have nearly identical biological activity in that they induce adhesion molecule expression on epithelial cells, control fever induction, and play a role in arthritis and septic shock. Signaling activated by the IL-1R1 promotes these activities through a MYD88 signaling pathway similar to those associated with Toll receptors. Recombinant human IL-1 beta is a non-glycosylated single chain.

Product Type:
Peptides & proteins
Alternative Names:
Catabolin, LAF, EP, LEM, MCF
Storage Temp:
-20°C
Limit of Detection:
17.4 kDa
Specifications:
PURITY (MIN.): ≥95
Additional Information:
Produced using animal free raw components and processes, in a non-mammalian system. Ideal for researchers concerned about the risks and effects of contaminating viruses, prions and trace growth factors from FBS and animal-derived ingredients used in standard recombinant protein production techniques. Endotoxin levels are less than 1.0 EU per ug protein via LAL. Bioactivity is comparable to recombinant protein produced in traditional techniques.