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IL-1 β

IL-1 β
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Size: 10 μg
$165.00
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Catalogue number:
GFH167-10
Name:
IL-1 β
Supplier:
Availability:

Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine produced in response to inflammatory agents by a variety of cells, including monocytes, macrophages, and dendric cells (DCs). IL-1 beta and IL-1 alpha are two distinct and independently regulated gene products that comprise IL-1 and signal through the Type 1 IL-1 receptor (IL-1R1). Although IL-1 alpha is cell associated and IL-1 beta is secreted, they have nearly identical biological activity in that they induce adhesion molecule expression on epithelial cells, control fever induction, and play a role in arthritis and septic shock. Signaling activated by the IL-1R1 promotes these activities through a MYD88 signaling pathway similar to those associated with Toll receptors. Recombinant human IL-1 beta is a non-glycosylated single chain.

Product Type:
Peptides & proteins
Alternative Names:
Catabolin, LAF, EP, LEM, MCF
Storage Temp:
-20°C
Limit of Detection:
17.5 kDa
Specifications:
PURITY (MIN.): ≥95
Additional Information:
NAME: Interleukin-1 beta; ACCESSION/UNIPROT#: P01584; EXPRESSION SYSTEM: E.coli; FORMAT: Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, pH 7.5. Reconstitute in sterile water at 0.1 mg/mL.; TESTING: D10S cell proliferation with an acceptance criteria of 12 pg/mL (ED50), 8.3 x 10^7 units/mg.; #AA: 154; SEQUENCE: MAPVRSLNCT LRDSQQKSLV MSGPYELKAL HLQGQDMEQQ VVFSMSFVQG EESNDKIPVA LGLKEKNLYL SCVLKDDKPT LQLESVDPKN YPKKKMEKRF VFNKIEINNK LEFESAQFPN WYISTSQAEN MPVFLGGTKG GQDITDFTMQ FVSS