Heterodimeric interleukin-17A/F is a member of the IL-17 family of six homodimeric proteins (IL-17A-17F). Recent IL-17A/IL-17F co-expression studies in HEK-293 cells revealed the presence of a biologically active heterodimer, IL-17A/F. Activated CD4+ T cells have also been shown to produce human IL-17A/F. Activity studies reveal hIL-17A to be the most potent, followed by hIL-17A/F and hIL-17F 100 fold lower than hIL-17A. IL-17A/F is thought to induce neutrophilia and chemokine expression via the IL-17RA receptor. Recombinant human IL-17A/F is a heterodimeric non-glycosylated polypeptide comprised of one monomeric subunit each of h-IL-17A and h-IL-17F.
Peptides & proteins
NAME: Interleukin-17AF Heterodimer; ACCESSION/UNIPROT#: Q16552/Q96PD4; EXPRESSION SYSTEM: E.coli; FORMAT: Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA). Reconstitute in sterile water at 0.1 mg/mL.; TESTING: Production of IL-3 by 3T3 cells with an acceptance criteria of 50 ng/mL (ED50), 2.0 x 10^4 units/mg.; #AA: 271; SEQUENCE: IL-17A:MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA IL-17F:MRKIPKVGHT FFQKPESCPP VPGGSMKLDI GIINENQRVS MSRNIESRST SPWNYTVTWD PNRYPSEVVQ AQCRNLGCIN AQGKEDISMN SVPIQQETLV VRRKHQGCSV SFQLEKVLVT VGCTCVTPVI HHVQ