IL-32 α

Human IL-32 alpha is one of approximately 6 splice variants of a gene cloned from the human lung carcinoma stable transfectant, A549-Rbeta. IL-32 alpha has been shown to induce IL-8, TNF-a, and MIP-2 production from human and mouse macrophage cell lines. It is upregulated in activated T- and NK-cells, and IFN-g-treated epithelial cells. Human recombinant IL-32 alpha is a non-glycosylated polypeptide.