ITAC / CXCL11

ITAC, or CXCL11, is one of three chemokines known to bind the receptor CXCR3 (the two others being CXCL9 (Mig) and CXCL10 (IP-10)). CXCL11 differs from the other CXCR3 ligands in that it has a higher receptor affinity and it acts as a stronger agonist. CXCL11 takes on the canonical chemokine fold but exhibits greater conformational flexibility than has been observed for related chemokines under the same sample conditions. Unlike related chemokines such as IP-10 and IL-8, ITAC does not appear to form dimers at mM concentrations. Recombinant Human ITAC produced in E. coli is a single, non-glycosylated, polypeptide chain.