VEGF-A was originally isolated from tumor cells. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating vasodilation via nitric oxide-dependent pathways. Alternative splicing of the mRNA for VEGF-A results in several isoforms of the protein being produced. Recombinant Human VEGF-121 is a double, non-glycosylated, polypeptide chain.
Peptides & proteins
VEGF-A, VPF, glioma-derived endothelial cell mitogen
NAME: Vascular Endothelial Growth Factor-121; ACCESSION/UNIPROT#: P15692-9; EXPRESSION SYSTEM: E.coli; FORMAT: Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA). Reconstitute in sterile water at 0.1 mg/mL.; TESTING: HUVEC proliferation with an acceptance criteria of 5 ng/mL (ED50), 2.0 x 10^5 units/mg.; #AA: 244; SEQUENCE: MAPMAEGGGQ NHHEVVKFMD VYQRSYCHPI ETLVDIFQEY PDEIEYIFKP SCVPLMRCGG CCNDEGLECV PTEESNITMQ IMRIKPHQGQ HIGEMSFLQH NKCECRPKKD RARQENCDKP RR