Transforming growth factor-betas (TGF betas) are multifunctional peptides that regulate growth and differentiation in a variety of cells. The TGF-beta family of growth modulators play critical roles in tissue development and maintenance. TGF-beta isoforms (TGF-beta 1, -beta 2 and -beta 3) have overlapping yet distinct biological actions and target cell specificities, both in developing and adult tissues. TGF beta 3 is a new isoform of the TGF beta superfamily and is presumed to play an important role in wound repair and scarring. TGF-beta 3 is believed to be involved in osteoblast proliferation, chemotaxis, and collagen synthesis. Recombinant Human TGF-b 3 is a disulfide-linked homodimer.
Peptides & proteins
TGF-β3 (0.25 mg/ml)
NAME: Transforming Growth Factor beta 3; ACCESSION/UNIPROT#: P10600; EXPRESSION SYSTEM: E.coli; FORMAT: In solution, 10 mM acetic acid and 20% Ethanol at a concentration of 0.25 mg/mL.; TESTING: Inhibition of IL-4-induced HT-2 cell proliferation with an acceptance criteria of 1 ng/mL (ED50), 1.0 x 10^6 units/mg.; #AA: 226; SEQUENCE: MALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY LRSADTTHST VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ LSNMVVKSCK CS