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ProTx-II (Cy5)

Catalogue number:
5 x 10 µg
Product is available in:
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Cy5-ProTx-II is a Cy5 fluorescently labeled ProTx-II, a famous Nav1.7 blocker. The wild type ProTx-II potently blocks Nav1.7 with an IC50 value of around 300 pM, Nav1.2, Nav1.5 and Nav1.6 with IC50 values of 41 nM, 79 nM and 26 nM respectively. It was shown to fully block Nav1.7 at 100 nM concentration. Cy5: λex 646nm , λem 662nm.

Product Type:

Peptides & proteins

Alternative Names:

Protoxin II, ProTx 2

Antibody Type:

Fluorescent Nav1.7 channel blocker


Middleton R. E., et al. (2002) Two tarantula peptides inhibit activation of multiple sodium channels, Biochemistry. PMID: 12475222

Storage Temperature:


Additional Information:

AA sequence: Tyr-Cys2-Gln-Lys-Trp-Met-Trp-Thr-Cys9-Asp-Ser-Glu-Arg-Lys-Cys15-Cys16-Glu-Gly-Met-Val-Cys21-Arg-Leu-Trp-Cys25-Lys-Lys-Lys-Leu-Trp-OH. Disulfide bonds: Cys2-Cys16, Cys9-Cys21, Cys15-Cys25

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