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Waglerin 1-FAM

Waglerin 1-FAM
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Size: 100 µg
$225.00
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Catalogue number:
WAG002-00100
Name:
Waglerin 1-FAM
Supplier:
Availability:

Waglerin-1-FAM is a nAChR blocker. Waglerin-1 (Wtx-1) is a peptide originally isolated from the venom of the Wagler’s pit viper (Trimeresurus wagleri). This 22 amino-acid peptide is a competitive antagonist of adult muscle nicotinic acetylcholine receptors. Waglerin-1 binds selectively to epsilon subunit of nAChR. Some studies have demonstrated that Waglerin-1 has an effect on ionotropic GABA receptors. It may potentiate or depress I(GABA) depending on the neurons. Some derivatives of Waglerin-1 are currently used in cosmetics to reduce wrinkles. The fluorescent derivative Waglerin-1-FAM can be use to explore the expression and function of the adult nAChR subtypes.

Applications:


nAChR blocker

Product Type:
Peptides & proteins
Alternative Names:
Wtx-1
Storage Temp:
Stable at room temperature under lyophilized powder. Store at -20°C for long term storage over 2 mon
Molecular Weight:
2878.27 Da
Reference:
Teichert RW. et al. Peptide-toxin tools for probing the expression and function of fetal and adult subtypes of the nicotinic acetylcholine receptor. Ann N Y Acad Sci. PMID: 18567854
Additional Information:
AA sequence: FAM-Gly-Gly-Lys-Pro-Asp-Leu-Arg-Pro-Cys9-His-Pro-Pro-Cys13-His-Tyr-Ile-Pro-Arg-Pro-Lys-Pro-Arg-OH; Disulfide bonds: Cys9-Cys13