Wortmannin
PI3K inhibitor / Potent and selective inhibitor of PI3-kinase which acts via covalent modification of Lys-8022. Inhibits autophagy in rat hepatocytes3. Inhibits adipocyte differentiation of 3T3-L1 cells4. A useful tool for probing PI3-K-mediated cellular events5.
Biochemicals & reagents
19545-26-7
1) Holleran et al. (2003), Use of high-performance liquid chromatography to characterize the rapid decomposition of wortmannin in tissue culture media; Anal. Biochem., 323 19 2) Wymann et al. (1996), Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction; Mol. Cell. Biol., 16 1722 3) Blommaart et al. (1997), The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes; Eur. J. Biochem., 243 240 4) Tomiyama et al. (1995), Wortmannin, a specific phosphatidylinositol 3-kinase inhibitor, inhibits adipocytic differentiation of 3T3-L1 cells; Biochem. Biophys. Res. Commun., 212 263 5) Ui et al. (1995), Wortmannin as a unique probe from an intracellular signaling protein, phosphoinositide 3-kinase; Trends Biochem. Sci., 20 303
-20°C
TARGET: Kinase -- PATHWAY: PI3K; Autophagy; Cell cycle -- RESEARCH AREA: Cell death