Necrostatin-34
Supplier:
Catalogue number:
10-4684-01
Size:
5 mg
Product is available in:
RIP1 kinase inhibitor / Necrostatin-34 is a selective inhibitor of RIP1 kinase. IC50s = 667 nM and 134 nM for TNFα in FAD-deficient Jurkat cells and L929 cells respectively. It binds to a site distinct from that of 7-Cl-O-Nec1 (Focus Cat# 10-4544) locking the enzyme in an inactive conformation. Necrostatin-34 acts synergistically with 7-Cl-O-Nec1 to inhibit necroptosis.
Product Type:
Biochemicals & reagents
CAS Number:
375835-43-1
Alternative Names:
Nec-34; 2-((3-Cyano-6-oxo-4-(p-tolyl)-1,4,5,6-tetrahydropyridin-2-yl)thio)-N-(thiazol-2-yl)acetamide
Reference:
Meng et al. (2021), Discovery of a cooperative mode of inhibiting RIPK1 kinase; Cell Discov. 7 41
Storage Temperature:
-20°C
Additional Information:
TARGET: Kinase -- PATHWAY: Necroptosis -- RESEARCH AREA: Cell death