N,N-Dimethylsphingosine
Sphingosine kinase inhibitor / Synthetic derivative of D-erythro-sphingosine (synthetic). Endogenous sphingolipid1. Inhibits sphingosine kinase (IC50 = 5µM)2. Induces apoptosis in a variety of cell lines3.
Biochemicals & reagents
119567-63-4
1) Igarashi et al. (1990), A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cells; J. Biol. Chem., 265 5385 / 2) Yatomi et al. (1996), N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets ; Biochemistry, 35 626 / 3) Gude et al. (2008), Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a “come-and-get-me” signal ; FASEB J., 22 2629
-20°C
TARGET: Kinase -- PATHWAY: Apoptosis inducer; Sphingolipid metabolism -- RESEARCH AREA: Cell death