Sphingosine
PKC inhibitor / Sphingosine is an inhibitor of protein kinase C (IC50 = 1-3 µM).1 It is abundant in cell membranes and is an important mediator in various biochemical pathways.2-4
Biochemicals & reagents
123-78-4
D(+)-erythro-1,3-Dihydroxy-2-amino-4-trans-octadecene
1) Merrill et al., (1989) Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds Biochemistry 28 3138 / 2) Ohanian and Ohanian (2001) Sphingolipids in mammalian cell signaling Cell.Mol.Life Science 58 2053 / 3) Ruvolo (2003) Intracellular signal transduction pathways activated by ceramide and its metabolites Pharm.Res. 47 383 / 4) Olivier (2002) Sphingosine in apoptosis signaling Biochim.Biophys.Acta 1585 153
-20°C
TARGET: Kinase -- PATHWAY: Sphingolipid metabolism; Apoptosis inhibitor; Lipid signaling -- RESEARCH AREA: Cell death