GSK8612
Supplier:
Catalogue number:
10-4693-02
Size:
25 mg
Product is available in:
Highly selective TBK1 inhibitor / Highly selective and potent (avg. pIC50 = 6.8 versus recombinant TBK1) inhibitor of Tank-binding Kinase-1 (TBK1) with higher affinity for unactivated TBK1. It inhibited phosphorylation of IRF3 (pIC50 = 6.0), inhibited the release of IFNa from human PBMC’s (pIC50 = 6.1), and inhibited IFNb secretion from THP-1 cells (pIC50 = 5.8 dsDNA virus, 6.3 cGAMP stilmulated cells).
Product Type:
Biochemicals & reagents
CAS Number:
2361659-62-1
Reference:
Thomson et al. (2019), Discovery of a GSK8612, a Highly Selective and Potent TBK1 Inhibitor; ACS Med. Chem. Lett., 10 780
Storage Temperature:
-20°C
Additional Information:
TARGET: Kinase -- PATHWAY: Cytokine; TLR signaling -- RESEARCH AREA: Neuroscience; Immunology -- DISEASE AREA: Inflammation; Cancer