Y-27632 dihydrochloride
ROCK family kinase inhibitor / Specific inhibitor of ROCK family kinases.1 Enhances stem cell survival and proliferation in culture.2 Significantly improves freeze/thaw survival rate for human embryonic stem cells without influencing morphology, karyotype, cell surface markers, or differentiation potential.3
Biochemicals & reagents
129830-38-2
1) Ishizaki et al. (2000), Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases; Mol. Pharmacol., 57 976 2) Gauthaman et al. (2010), Effectis pf ROCK Inhibitor Y-27632 on Normal and Varient Human Embryonic Stem Cells (hESCs) In Vitro: It’s Benefits in hESC Expansion; Stem Cell Rev., 6 86 3) Li et al. (2008), the ROCK Inhibitor Y-27632 enhances the Survival Rate of Human Embryonic Stem Cells Following Cryopreservation; Stem Cells Dev., 17 1079
-20°C
TARGET: Kinase -- PATHWAY: Proliferation; Senescence; Cell migration -- RESEARCH AREA: Stem cells -- DISEASE AREA: Inflammation; AgeingDiabetes