GSK-3 inhibitor / Potent and selective inhibitor of glycogen synthase kinase-3 (GSK-3) IC50=5 nM1. The first pharmacological agent shown to maintain self-renewal in human and mouse embryonic stem cells2 . Promotes proliferation in mammalian cardiomyocytes2 A potent inhibitor of malignant lymphoid cell proliferation3.
Biochemicals & reagents
667463-62-9
1) Meijer et al. (2003), GSK-3-selective inhibitors derived from Tyrian purple indirubins; Chem. Biol., 10 1255 2) Tseng et al. (2006), The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes; Chem. Biol., 13 957 3) Chebel et al. (2009), Indirubin derivatives inhibit malignant lymphoid cell proliferation; Leuk. Lymphoma, 50 2049
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TARGET: Kinase -- PATHWAY: Carbohydrate metabolism; Proliferation; Wnt; GSK3 -- RESEARCH AREA: Stem cells -- DISEASE AREA: Heart disease