UH15-38·2HCl
Supplier:
Catalogue number:
10-4862-01
Size:
5 mg
Product is available in:
RIP3K inhibitor / UH15-38 is a potent (IC50 = 20 nM) inhibitor of RIPK3 with excellent cellular activity. It blocked TNF-induced necroptosis in primary mouse embryonic fibroblasts (IC50 = 98 nM). UH15-38 selectively blocked influenza A-induced necroptosis over apoptosis in mouse alveolar epithelial cells, mouse embryonic fibroblasts, and human M29 cells at nanomolar levels. It attenuated influenza A-induced lung injury and lethality in vivo.
Product Type:
Biochemicals & reagents
CAS Number:
2540881-21-6
Reference:
1) Gautam et al. (2024), Necroptosis blockade prevents lung injury in severe influenza; Nature 628 835
Storage Temperature:
-20°C
Additional Information:
TARGET: Kinase -- PATHWAY: Necroptosis -- RESEARCH AREA: Cell death -- DISEASE AREA: Infectious disease