Nonactin
Monovalent cation ionophore (K+ and NH4+) / Monovalent cation ionophore with high selectivity for NH4+ and K+1. Upregulates levels of mitochondrial stress proteins HSP58 and GRP752. Abolishes mitochondrial membrane potential3.
Biochemicals & reagents
6833-84-7
Polynactin; Werramycin A
1) Garcia et al. (2003), Determination of potassium ions in pharmaceutical samples by FIA using a potentiometric electrode based on ionophore nonactin occulded in EVA membrane; J. Pham. Biomed. Anal., 31 11 2) Mizzen et al. (1989), Identification, characterization and purification of two mammalian stress proteins present in mitochondria, grp 75, a member of the hsp 70 family and hsp 58, a homolog of the bacterial groEL protein; J. Biol. Chem., 264 20664 3) Dudani et al. (1990), Effects of antimitotic and antimitochondrial agents on the cellular distribution of microtubules and mitochondria; Cytobios, 63 95
-20°C
TARGET: Ionophore -- PATHWAY: Mitochondrial function -- RESEARCH AREA: Cellular stress