Damnacanthal
p56 Lck inhibitor / Potent inhibitor of p56lck tyrosine kinase activity (IC50 = 17 nM for inhibition of autophosphorylation). Displays 7- to 20-fold selectivity over p59fyn and p60src tyrosine kinases and > 40-fold to 100-fold selectivity over other kinases1. Mobilizes intracellular Ca2+ in dermal fibroblasts2. Inhibits LIM-kinase, impairing cell migration and invasion3. A potent inhibitor of angiogenesis4. Inhibits mast cell activation5.
Biochemicals & reagents
477-84-9
1) Faltynek et al. (1995), Damnacanthal is a highly potent, selective inhibitor of p56lck tyrosine kinase activity; Biochemistry, 34 12404 2) Aoki et al. (2000), Mechanism of damnacanthal-induced ;Ca(2+)](i) elevation in human dermal fibroblasts; Eur. J. Pharmacol., 387 119 3) Ohashi et al. (2014), Damnacanthal, an effective inhibitor of LIM-kinase, inhibits cell migration and invasion; Mol. Biol. Cell, 25 828 4) Garcia-Vilas et al. (2017), The noni anthraquinone damnacanthal is a multi-kinase inhibitor with potent anti-angiogenic effects; Cancer Letters, 385 1 5) Garcia-Vilas et al. (2015), Damnacanthal inhibits IgE receptor-mediated activation of mast cells; Mol. Immunol., 65 86
-20°C
TARGET: Kinase -- PATHWAY: Calcium signaling; Cell migration -- RESEARCH AREA: Angiogenesis -- DISEASE AREA: Cancer