Veratridine
Na channel opener / A steroidal alkaloid. Voltage-gated Na+ channel activator1. May be used to increase Na+ concentration in cardiomyocytes2 and in cultured sympathetic neurons3. Toxic: LD50=1.35 mg/Kg (mouse i.p.)
Biochemicals & reagents
71-62-5
1) Fekete et al. (2009), Mechanism of the persistent sodium current activator veratridine-evoked Ca elevation: implication for epilepsy; J. Neurochem., 111 745 2) Chen et al. (1997), Differential effects of CA2+ channel blockers on Ca2+ overload induced by lysophosphatidylcholine in cardiomyocytes; Eur. J. Pharmacol., 333 261 3) Koike et al. (2000), Sodium overload through voltage-dependent Na(+) channels induces necrosis and apoptosis of rat superior cervical ganglion cells in vitro; Brain Res. Bull., 51 345
-20°C
TARGET: Ion channel -- PATHWAY: Sodium channel -- RESEARCH AREA: Neuroscience