ICA-110381
Supplier:
Catalogue number:
10-1467-01
Size:
5 mg
Product is available in:
Kv7.2/7.3 activator / A KCNQ2/Q3 (Kv7.2/7.3) activator, EC50=0.38 uM (KCNQ1 IC50=15uM)1. KCNQ3/Q5 heterodimers are not affected2. Potently dampens neuronal excitability and displays anticonvulsant activity in vivo2.
Product Type:
Biochemicals & reagents
CAS Number:
325457-99-6
Reference:
1) Amato et al. (2011), N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy; Sci. ACS Med. Chem. Lett., 2 481 2) Boehlen et al. (2013), The new KCNQ2 activator 4-Chlor-N-(6-chlor-pyridin-3-yl)benzamid displays anticonvulsant potential; Br. J. Pharmacol., 168 1182
Storage Temperature:
RT
Additional Information:
TARGET: Ion channel -- PATHWAY: Potassium channel -- RESEARCH AREA: Neuroscience