Amlodipine
L-type Ca channel blocker / Anti-hypertensive L-type calcium channel blocker, which also benefits the cardiovascular system by stimulating nitric oxide synthase, inhibiting angiotension-induced oxidative stress and cardiovascular injury, and inhibiting monocyte/endothelial adhesion. Amlodipine also has a longer duration of action as compared to other similar calcium channel blockers.
Biochemicals & reagents
88150-42-9
1) Mason et al. (2003), Novel vascular biology of third-generation L-type calcium channel antagonists: ancillary actions of amlodipine; Arterioscler. Thromb. Vasc. Biol., 23 2155 / 2) Asano et al. (2003), A calcium channel blocker activates both ecto-5(‘)-nucleotidase and NO synthase in HUVEC; Biochem. Biophys. Res. Commun., 311 625 / 3) Yu et al. (2003), Amlodipine modulates THP-1 cell adhesion to vascular endothelium via inhibition of protein kinase C signal transduction; Hypertension, 42 329 / 4) Zhou et al. (2004), Inhibition of oxidative stress and improvement of endothelial function by amlodipine in angiotensin II-infused rats; Am. J. Hypertension, 17 167 / 5) Ueda et al. (1993), A comparative assessment of the duration of action of amlodipine and nifedipine GITS in normotensive subjects; Br. J. Clin. Pharmacol., 36 561
RT
TARGET: Ion channel -- PATHWAY: Calcium signaling; Cell adhesion -- RESEARCH AREA: Oxidative stress