Cromakalim
ATP-sensitive potassium channel opener / A potent and selective ATP-sensitive potassium channel (KATP or Kir6) opener.1 Dose dependently prevents or suppresses hyperalgesia and allodynia in a sciatic nerve injury model.2 Displays ocular hypotensive and neuroprotective properties.3 Attenuates morphine chronic antinociceptive tolerance.4
Biochemicals & reagents
94470-67-4
BRL-34915
1) Sanguinetti et al. (1988), BRL 34915 (cromakalim) activates ATP-sensitive K+ current in cardiac muscle; Proc. Natl. Acad. Sci. USA, 85 8360 2) Wu et al. (2011), Reopening of ATP-sensitive potassium channels reduces neuropathic pain and regulates astroglial gap junctions in the rat spinal cord; Pain, 152 2605 3) Roy Chowdhury et al. (2017), ATP sensitive potassium channel openers: A new class of ocular hypotensive agents; Exp. Eye Res., 158 85 4) Cao et al. (2016), Opening of the Adenosine Triphosphate-sensitive Potassium Channel Attenuates Morphine Tolerance by Inhibiting JNK and Astrocyte Activation in the Spinal Cord; Clin. J. Pain, 32 617
RT
TARGET: Ion channel -- PATHWAY: Potassium channel -- DISEASE AREA: Pain; Hypertension