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Cromakalim

Supplier:
Catalogue number:
10-3228-02
Size:
25 mg
Product is available in:
  • USA
  • Canada
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ATP-sensitive potassium channel opener / A potent and selective ATP-sensitive potassium channel (KATP or Kir6) opener.1 Dose dependently prevents or suppresses hyperalgesia and allodynia in a sciatic nerve injury model.2 Displays ocular hypotensive and neuroprotective properties.3 Attenuates morphine chronic antinociceptive tolerance.4

Product Type:

Biochemicals & reagents

CAS Number:

94470-67-4

Alternative Names:

BRL-34915

Reference:

1) Sanguinetti et al. (1988), BRL 34915 (cromakalim) activates ATP-sensitive K+ current in cardiac muscle; Proc. Natl. Acad. Sci. USA, 85 8360 2) Wu et al. (2011), Reopening of ATP-sensitive potassium channels reduces neuropathic pain and regulates astroglial gap junctions in the rat spinal cord; Pain, 152 2605 3) Roy Chowdhury et al. (2017), ATP sensitive potassium channel openers: A new class of ocular hypotensive agents; Exp. Eye Res., 158 85 4) Cao et al. (2016), Opening of the Adenosine Triphosphate-sensitive Potassium Channel Attenuates Morphine Tolerance by Inhibiting JNK and Astrocyte Activation in the Spinal Cord; Clin. J. Pain, 32 617

Storage Temperature:

RT

Additional Information:

TARGET: Ion channel -- PATHWAY: Potassium channel -- DISEASE AREA: Pain; Hypertension