AP-18
TRPA1 blocker / TRPA1 channel blocker IC50=3.1-4.5 μM in various cell lines. Reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation. Does not block TRPV1, V2, V3, V4 or M8 at concentrations up to 50 μM.1 Blocks TRPA1 pore dilation (IC50=10.3 μM).2 An important tool for assessing the role of TRPA1 in cell signaling and physiological processes.3-5
Biochemicals & reagents
55224-94-7
1) Petrus et al (2007) A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition. Mol.Pain 3 40 2) Chen et al. (2009) Pore dilation occurs in TRPA1 but not in TRPM8 channels; Mol. Pain, 5 3 3) Lieder et al. (2017) The Alkamide trans-Pellitorine Targets PPAR? via TRPV1 and TRPA1 to Reduce Lipid Accumulation in Developing 3T3-L1 Adipocytes; Front. Pharmacol., 8 316 4) Chepurny et al. (2016) GPR119 Agonist AS1269574 Activates TRPA1 Cation Channels to Stimulate GLP-1 Secretion; Mol. Endocrinol., 30 614 5) Cheah et al. (2014) Acrolein relaxes mouse isolated tracheal smooth muscle via a TRPA1-dependent mechanism; Biochem. Pharmacol., 89 148
RT
TARGET: Ion channel -- PATHWAY: Cation channel -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Pain