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ML335

Supplier:
Catalogue number:
10-3648-01
Size:
5 mg
Product is available in:
  • USA
  • Canada
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TREK-1,2 activator / Two-pore domain potassium (K2P) channels of the TREK subfamily regulate neuronal excitability, influence pain, temperature perception and responses to anaesthetics. ML335 is a novel, selective TREK-1,2 activator with EC50s of 14.3 and 5.2 uM1. It represents an important new pharmacological tool for studying the physiology of TREK channels.

Product Type:

Biochemicals & reagents

CAS Number:

825658-06-8

Reference:

1) Lolicato et al. (2017), K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site; Nature, 547 364

Storage Temperature:

-20°C

Additional Information:

TARGET: Ion channel -- PATHWAY: Potassium channel -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Pain