Smoothened agonist / Smoothened agonist which bind directly to SMO and can block SMO inhibition by cyclopamine. The conformation of SMO is altered by SAG binding which results in the accumulation of SMO in cilia and activated gene transcription. It should be noted that SAG inhibits hedgehog signaling at concentrations greater than 1 µM (EC50 for SMO activation is ~ 3 nM).1
Product Type:
Biochemicals & reagents
CAS Number:
364590-63-6
Alternative Names:
Smoothened Agonist
Reference:
1) Chen et al. (2002), Small molecule modulation of Smoothened activity; Proc. Natl. Acad. Sci. USA, 99 14071
Storage Temperature:
-20°C
Additional Information:
TARGET: GPCR -- PATHWAY: Hedgehog -- RESEARCH AREA: Neuroscience