GRI-977143
LPA2 antagonist / Selective agonist of the lysophosphatidic acid - 2 (LPA2) receptor. Displays antiapoptotic activity.1 Rescues apoptotically condemned cells from death and injury caused by high-dose γ-irradiation in vitro and in vivo. Rescues mice from deadly levels of radiation when given 24 hours post-exposure.2 Activates the ERK1/2 prosurvival pathway.2
Biochemicals & reagents
325850-81-5
1) Kiss et al. (2012), Virtual screening for LPA2-specific agonists identifies a nonlipid compound with antiapoptotic actions; Mol.Pharmacol. 82 1162 2) Kiss et al. (2013), Mitigation of radiation injury by selective stimulation of the LPA2 receptor; Biochim.Biophys.Acta 1831 117
-20°C
TARGET: GPCR -- PATHWAY: ERK; Apoptosis inhibitor -- RESEARCH AREA: Cell death