Prostaglandin A1
Endogenous prostaglandin / PGA1 is a naturally occurring prostaglandin with diverse biological actions including anti-hypertensive1,2, anti-inflammatory3,4, anti-viral5,6, and anticancer7,8.
Biochemicals & reagents
14152-28-4
PGA1
1) Lee et al. (1972) Renal effects of prostaglandin A1 in patients with essential hypertension; Kidney Int. 1 254 2) Toppozada et al. (1988) Treatment of preeclampsia with prostaglandin A1; Am.J.Obstet.Gynecol. 159 160 3) Rossi et al. (2000) Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase; Nature 403 103 4) Mandal et al. (2005), Yin-yang: balancing act of prostaglandins with opposing functions to regulate inflammation; J.Immunol. 175 6271 5) Carta et al. (2014) Prostaglandin A1 inhibits avian influenza virus replication at a postentry level: Effect on virus protein synthesis and NF-kB activity; Prostaglandins Leukot.Essential Fatty Acids 91 311 6) Tsukimoto et al. (2015) A new role for PGA1 in inhibiting hepatitis C virus-IRES-mediated translation by targeting viral translation factors; Antiviral Res. 117 1 7) Diez-Dacal et al. (2011) Identification of aldo-keto reductase AKR1B10 as a selective target for modification and inhibition by prostaglandin A(1): implications for antitumoral activity; Cancer Res. 71 4161 8) Anta et al. (2016), PGA1-induced apoptosis involves specific activation of H-Ras and N-Ras in cellular endomembranes; Cell Death Dis. 7 e2311
-20°C
TARGET: GPCR -- PATHWAY: Lipid signaling -- DISEASE AREA: Inflammation; CancerInfectious disease