NA-Gly
GPR18 agonist / Endogenous anti-inflammatory lipo-aminoacid1. Full agonist at GPR182,3. Induces macrophage apoptosis via GPR184 which may be a mechanism for its resolution of inflammation activity5.
Biochemicals & reagents
179113-91-8
N-Arachidonylglycine
1) Huang et al. (2001), Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain; J. Biol. Chem., 276 42639 / 2) McHugh et al. (2012), Δ(9)-Tetrahydrocannabinol and N-arachidonylglycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells; Br. J. Pharmacol., 165 2414 / 3) McHugh et al. (2012), siRNA knockdown of GPR18 receptors in BV-2 microglia attenuates N-arachidonyl glycine-induced cell migration; J. Mol. Signal., 7 10 / 4) Takenouchi et al. (2012), N-arachidonyl glycine induces macrophage apoptosis via GPR18; Biochem. Biophys. Res. Commun., 418 366 / 5) Burstein et al. (2011), Resolution of inflammation by N-arachidonoylglycine; J. Cell Biochem., 112 3227 / 6) [FOCUS CITATION] Console-Bram et al. (2017), N-arachidonoyl glycine, another endogenous agonist of GPR55; Biochem. Biophys. Res. Commun., 490 1389
-20°C
TARGET: GPCR -- PATHWAY: Apoptosis inducer; Lipid signaling; Cannabinoid receptor -- RESEARCH AREA: Cell death -- DISEASE AREA: Inflammation; Diabetes