TG 4-155
EP2 receptor antagonist / Potent and selective prostaglandin EP2 receptor antagonist, KB = 2.4 and 34.5 nM for EP2 and DP1 receptors respectively. Displays >500-fold selectivity for EP2 over other prostanoid receptors.1 Inhibits butaprost-induced proinflammatory cytokine production, cell proliferation and invasion of PC-3 cells in vitro.2 Inhibits PGE2-induced inflammatory response and may represent a novel pharmacologic intervention for tumorigenesis resulting from inflammation.1
Biochemicals & reagents
1164462-05-8
1) Jiang and Dingledine (2013), Role of prostaglandin receptor EP2 in the regulations of cancer cell proliferation, invasion, and inflammation; J. Pharmacol. Exp. Ther. 344 360 2) Quan et al. (2013), EP2 Receptor Signaling Pathways Regulate Classical Activation of Microglia; J. Biol. Chem. 288 9293
-20°C
TARGET: GPCR -- PATHWAY: Lipid signaling; Cytokine; Proliferation -- DISEASE AREA: Inflammation; Cancer