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AdipoRon

Supplier:
Catalogue number:
10-1483-02
Size:
50 mg
Product is available in:
  • USA
  • Canada
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Adiponection agonist / A novel potent and selective adiponectin (AdipoR1 and AdipoR2) receptor agonist, Kd=1.8 and 3.1 μM respectively1. Displayed similar effects to adiponectin in muscle and liver such as activation of PPARα and AMPK signaling pathways. It also reversed insulin resistance and glucose intolerance in mice on a high-fat diet. It ameliorated diabetes in a genetically obese mouse model and prolonged the shortened lifespan of db/db mice on a high-fat diet1. Active in vivo.

Product Type:

Biochemicals & reagents

CAS Number:

924416-43-3

Reference:

1) Okada-Iwabu et al. (2013), A small-molecule AdipoR agonist for type 2 diabetes and short life obesity; Nature, 503 493

Storage Temperature:

RT

Additional Information:

TARGET: GPCR -- PATHWAY: AMPK pathway; PPAR; Transcription -- DISEASE AREA: Diabetes; ObesityLiver disease